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In Summer 2003, a National Institute of Health study determined that hormone replacement therapy (HRT) contributed to increased risk of heart disease, some types of cancer, stroke, and Alzheimer's disease.

Recently, hearing, asthma, and--ironically--incontinence have been added to the "Increased Risk" list. For links to other studies you may find interesting:

www.mayoclinic.com/health/hormone-therapy/WO00046


Hormone therapy increases risk of
  • Heart disease
  • Breast cancer
  • Stroke
  • Blood clots
  • Dementia

From the FDA http://www.fda.gov/cder/foi/label/2006/020527s037lbl.pdf

Premerin Prempro and Premaphase can cause the following side effects:
  • Breast cancer
  • Cancer of the uterus
  • Stroke
  • Heart attack
  • Blood clots
  • Dementia
  • Gallbladder disease
  • Ovarian cancer
These are some of the warning signs of serious side effects:
  • Breast lumps
  • Unusual vaginal bleeding
  • Dizziness and faintness
  • Changes in speech
  • Severe headaches
  • Chest pain
  • Shortness of breath
  • Pains in your legs
  • Changes in vision
  • Vomiting
Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptoms that concerns you.

Common side effects include:
  • Headache
  • Breast pain
  • Irregular vaginal bleeding or spotting
  • Stomach/abdominal cramps/bloating
  • Nausea and vomiting
  • Hair loss
Other side effects include:
  • High blood pressure
  • Liver problems
  • High blood sugar
  • Fluid retention
  • Enlargement of benign tumors of the uterus (“fibroids”)
  • Vaginal yeast infections
  • Mental depression
These are not all the possible side effects, just the most common.